Polynucleotides

Teach your skin to repair itself.

The regenerative treatment everyone's asking about: purified salmon DNA that switches your skin back into repair mode. Extraordinary for tired under-eyes.

From £10030 minutesCourse of 3 £260Under-eye hero

Regeneration, not disguise.

Filler adds volume; polynucleotides do something cleverer. These purified DNA fragments, remarkably compatible with human skin, signal your fibroblasts to produce fresh collagen and elastin, calm inflammation, and deeply hydrate from within. The skin doesn't just look better; it genuinely behaves younger.

‘Didn’t you sleep last night?’ If you’re asked that after a full eight hours, this is your treatment. The under-eye area is where polynucleotides shine. Dark, crepey, hollow-looking eyes are often unsafe or unsuitable for filler, but respond beautifully to regeneration, brightening and thickening delicate skin over a short course.

Yes, it comes from salmon — and yes, everyone asks. It's precisely because salmon DNA is so similar to ours that it's accepted by the skin without reaction. Results build over weeks and improve with each session; we recommend a course of two or three, spaced a few weeks apart, then a top-up around every six months.

What happens at your appointment

  • Skin assessment: under-eyes, cheeks, neck or wherever quality has dipped.
  • Numbing cream while the product comes to temperature.
  • A pattern of tiny superficial injections across the area.
  • Tiny blebs settle within 24–48 hours; the glow builds over the following weeks.

Medically reviewed by Katie, Independent Nurse Prescriber · July 2026

Good to know

Questions, answered honestly.

What are polynucleotides? +
Regenerative injectables made from purified, fragmented salmon DNA. Rather than filling, they stimulate your own collagen, elastin and hydration, improving skin quality itself.
Why salmon DNA? +
Salmon DNA is highly purified and structurally very similar to human DNA, so the skin accepts it readily without reaction. It's the same reason it's used in wound-healing medicine.
Are they better than filler under the eyes? +
For most people, yes. Under-eye filler can look puffy or migrate; polynucleotides thicken and brighten the delicate skin instead, treating the cause of the tired look.
How many sessions do I need? +
We recommend a course of two or three, two to four weeks apart, with results building for up to twelve weeks after. A single maintenance session every six months keeps it.
Is there downtime? +
Minimal. Small raised blebs at the injection points settle within a day or two, easily covered once healed.

Ready when you are.

Free consultations, honest advice, and the pink door of Oxton Village waiting for you.

Book your appointment

Glow now, pay later.

Spread the cost of any treatment with flexible finance at checkout.

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